IITC Life Science Electronic von Frey Anesthesiometer for Mice and Rats
The IITC Life Science the original Electronic von Frey Aestehsiometeris used to assess mechanical allodynia with rigid tips (threshold) and the “Supertips™” (flexible von Frey hairs) are used for sensory test on all test subjects from all animal test subjects and human studies.
Features
Description
| Part # | Description |
| 2390 | Electronic von Frey rigid tips only included, 90 gram range |
| 2391 | Electronic von Frey rigid tips only included, 800 gram range |
| 2392 | Electronic von Frey rigid and 15 Supertips included, 90 gram range |
| 2393 | Electronic von Frey rigid and 15 Supertips included, 800 gram range |
| 23931 | Electronic von Frey custom rigid tips only included, 1000 gram range |
| 2394 | Probe only, 90 gram range |
| 2395 | Probe only, 800 gram range |
| 2396 | Probe only, 1000 gram range |
| 2397 | MRI Probe |
| 2400 | Analog output cable |
The 2390 series enables researchers to use up to 5 total test disciplines wath a single unit. Multiple users have the ability to use one single unit for multiple studies.
Our system is the first system introduced to the market over 11 years ago which finally allows researchers the ability to test and automatically record pain threshold values in a clean, accurate easy to use compact system.
The systems are supplied with either a 90, 800 or 1000 gram probe. Probe type is determined by test subject.
When studies call for pain threshold, rigid tips are used when measuring sensory threshold one of the 15 Supertips™ are used. The IITC hairs are unique in design – each hair has a uniform tip of .8mm in diameter, eliminating the possibility of false readings that may occur due to the varying hair thickness when applied to test subject.
The systems will allow you to measure, store and display your test readings in grams based upon the amount of pressure applied. Manually calculating results is no longer required with the IITC system.
Testing is simple, choose one of the supplied tips place on probe tip; apply pressure probe to test subject, upon reaction the unit will display and store your reading in grams, an easy, quick test system for all pain studies.
An internal load cell is attached to the small tip, this is the central element in the system; which connected to the electronic system allows you digitally record your test results.
All EVF systems are calibrated at the factory and do not require any type of constant calibration, adjustment or separate calibrator to be purchased.
The optional analog output cable supplies a pressure analog output voltage (mV range) exactly proportional to the applied pressure. The signal is free floating and can be used on both chart recorders and/or AD converters.
Our system is an easy, user friendly system which was developed to replace the traditional hairs but at the same time enabling researchers to not only test sensory but pain threshold in one system.
What are “Supertips™”
As reported by earlier papers varying probe diameter on von Frey hairs is a serious problem. These patented “Supertips™” have a UNIFORM TIP DIAMETER OF .8mm ON ALL 15 DIFFERENT VON FREY HAIRS! This is a unique feature available only on Electronic von Freys by IITC Inc. Probe size no longer affects pain or pressure thresholds and results are finally comparable! All tips can be ordered individually.
This instrument eliminates the poor data collection due to the hygroscopic nature of von Frey hairs (it is proven that relative humidity can change the force by more than 100% between 28-52% relative humidity change!) Only an accurate readout can show the actual force, not a number as on the handle of classic von Frey handles. Bending at various degrees can change the force by 20-30% in every case, this is visible with an electronic readout only. The natural limiting of force with flexible hairs is of great advantage. This instrument makes the up-down method of finding threshold unnecessary. Without using line adapter, Battery life is 50 hours. (Supplied)
One year warranty
120/240V
CE
Literature Reference:
1. Effects on Birth Weight and Adult Health in Rats Prenatally Exposed to Toxicants or Undernutrition.
Brain E. Grey, Brenda Barbee, Kaberi Das, Joel Norwood, Christopher Lau, and John M. Rogers.
Reproductive Toxicology Division, NHEERL, ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC
Poster Presented at SOT 2007
2. Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonist
Ranjinidevi Ambalavanar, Masayuki Moritani, Aicha Moutanni, Panduranga Gangula, Chandrasekha Yallampalli, Dean Dessem
Pain 120 (2007) 53-68
3. Evaluation of a von Frey Device for Pharmacoddynamic Modeling of Morphine in Dogs.
Butch KuKanich, B. Duncan X. Lascelles, Mark G. Papich
Comparatrive Pain and Pharmacology Research Laboratories
4. An electronic pressure-meter nociception paw test for rats
G.G. Vivancos, W.A. Verri Jr, T.M. Cunha, I.R.S. Schivo, C.A. Parada,
F.Q. Cunha and S.H. Ferreira
Brazilian Journal of Medical and Biological Research (2004) 37:391-399
5. An electronic pressure-meter nociception paw test for rats
G.G. Vivancos, W.A. Verri Jr, T.M. Cunha, I.R.S. Schivo, C.A. Parada,
F.Q. Cunha and S.H. Ferreira
Brazilian Journal of Medical and Biological Research (2004) 37:401-407
6. Assessment of von Frey device for evalution of the antinociceptive effects of morphine and its application in pharmacodynamic modeling of morphine in dogs
Butch KuKanich, DVM, PhD; B. Duncan X. Lascelles, BVSc, PhD; Mark G. Papich, DVM, MS
American journal of Veterinary Research 2005 66(9).
7. Cairns BE, Gambarota G, Svensson P, Arendt-Nielsen L, Berde CB. Glutamate-induced sensitization of rat masseter muscle fibers. Neuroscience, 2002; 109: 389-399.
8. Arpad Dobolyi, Hiroshi Ueda, Hitoshi Uchida, Miklos Palkovits, and Ted B. Usdin, Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. , , PNAS, February 5, 2002, volume. 99, no. 3, 1651 to 1656
9. Jensen K. Andersen et al: Pressure-Pain threshold In Human Temporal Region. Evaluation of A New Pressure Algometer Pain, 1986;25:313-23. (This is why”SupertipsTM” exist!) Poster at IASP Congress San Diego 2002
10. 437-P71 Performance of Von frey polyamide Monofilaments During Changes in relative Humidity: A Calibration Study. Per R. Neilsen, Mads U. Werner, Catarina Ellehuus. Dept Anesthesiology, Univ Hospital, Hvidovre, Denmark (spon: Per R. Nielsen)
11. Assessment of Stimulation Parameters Used In Measuring Mechanical Hyperalgesia In Animal Models Of Pain. Harry J. Gould, III, R. Denis Soignier, Porter Nolan, Sarah J. Vitale, and Dennis Paul. Departments of Neurology and Pharmacology, and Neuroscience Center of Excellence LSU Health Sciences Center, New Orleans, LA, USA 70112
12. Abstract: Validation of an Electronic Von Frey Device in a Rat Model of Incisional Pain and its use in Assessing the Efficacy of Clinically Relevant Analgescis. L. Mark; G. Whiteside, J. Boulet, K. Walker., Discovery Research, Purdue Pharma, Cranbury, NJ, USA (presented at SFN 2003)
Specs
Articles
FAQ's
- What test subjects can the EVF be use on?
Humans, mice, rats, cats, dogs, monkeys, the most universal system on the market.
- What are the “Flexible von Frey hairs”?
They are 15 individual hairs with an 8 mm uniform tip diameter on each hair. Why? Because the varying tip diameters can cause false reactions to the difference in the amount of hair touching test subjects in the traditional hairs and that is the reason IITC developed the “uniform tip diameter”.
- What is the maximum range of the probes?
Depending on which probe is ordered will determine the maximum force range the probe will allow. When testing mice the 90 gram probe should be ordered. When testing rats and other larger test subjects the 400 (now 800 gram supplied) probe should be ordered. When testing larger subjects (dogs, cats, monkeys) the 100 gram probe should be ordered.
- My research will be for pain and or sensory reactions, which system should I order?
If your studies will include both pain threshold and sensory values then both the rigid tips as well as the 15 flexible von Frey hairs need to be ordered to allow measurement of both.
- Am I able to perform all three of the following tests with one system? (EVF, Digital Randall Selitto and Paw Edema Test
Yes absolutely! A true first on the market which will finally allow you to purchase one of the three available systems complete and the only additional purchase required is the individual modules to perform the various tests in one electronic system.
- Do I need to order your complete Mesh Test Stand?
No it is not required to be ordered for the EVF testing but is recommended when you studies will have a large group of animals in the study. the animal enclosure allows up to 6 rats and 12 mice in one enclosure supplied standard. Or if your studies will be with a smaller group of animals the smaller Mesh Stand may be ordered – 2 rats – 4 mice.
- How many probes am I able to have connected to the electronics?
A total of three pressure probes can be connected at any one time.
- What is the warranty supplied on the system?
One year warranty supplied.
- How does your Electronic von Frey system differ from the traditional hairs?
Our system will record, display and store the readings of the pressure of the test subjects reaction in the electronics. No need to test and manually record data. all data is displayed and stored.
- How accurate is the system?
It is the most accurate system on the market today. It has been compared to the traditional von frey hairs and has come out far ahead with the statement that “If one is to test allodynia then the best method or choice would be the IITC Life Science Electronic von Frey.
