Plantar
Test Apparatus (Hargreaves Test Method)
6 Rats and 12 Mice standard
The Plantar Test (Hargreaves
method) is used for the paw withdrawal test (thermal
hyperalgesia testing) the use of visible light in our
systems is favorable to the infrared light; since one
will not always know when the test subject will react.
These Plantar test systems prevent false starts and
stops for the above reason.


- No clicking noises that
precondition animals
- Humane cut-off feature,
set by user
- Adjustable beam intensity
in 1% increments
- Manual override of all
timer functions
- Easy keypad entry of
all data
- Unrestrained animals
- Heated glass option only from
IITC Life Science
- RS232 Standard
- Printer output standard
- Footswitch standard
- Software for data collection
(optional)
- Thermal printer (optional)

The
IITC Plantar Test Analgesia Meter for paw withdrawal latency
on mice, rats and other animals (cats, rabbits) used to
test the properties of narcotic and stronger non-narcotic
drugs on unrestrained
mice and rats. The test is made on the plantar surface of
rodents by a focused, radiant heat light source which emits
from the test head. The test head is placed under a tempered
glass surface and slides on top of the supplied base with
Teflon balls to the desired position. The light beam is
focused to the top of the glass and creates a 4X6mm intense
spot on the paw. Prior to testing there is a “guide”
light to assist in directing the beam to the precise spot.
An adjustable angled mirror is mounted on top of the test
head to help the operator to view the paw without constant
bending. The use of visible light compares favorably with
an infrared light source since the user does not always
know exactly where the test will start, this causes false
starts and conditioning of animals.
Mirror for sight alignment
on animal subject

All functions and parameters
are entered via the Key-pad:
- Animal number, allows
the user to enter a two digit ID number so that the
animal can be tracked.
- Active Intensity, is
the intensity of the stimulation light during any given
test being done. From 0% to 100% light intensity(brightness).
- Idle Intensity, This
is the intensity of the stimulation light during the
ready state. 0% to 100% light intensity (brightness).
- Cutoff time, length
of time from the start of the test until the unit will
automatically end the test, from 0 (Off) to 99 seconds.
This feature prevents the tissue damage.
- Time of Day, time is
entered
- Date, date is entered
The instrument has a built-in
timer which displays the reaction time in .01 second
incre-ments. A push-button mounted into the handle of
the test head allowing the operator to stop the test
cycle, thus eliminating false triggering. A sturdy, acrylic
animal enclosure is placed on top of the glass and has
room for six rats at a time and twelve for mice. The
height of the glass is adjust-able and thereby the focal
point of the light is adjustable allowing to stimulate
other body parts. A Humane cut-off timer is standard.
The unit can be preset for a cut-off period, at the end
of which the light beam is shut off automatically if
the animal has not responded, avoiding any tissue damage.
The test head is silent without emitting any clicking
or whining noises as reported on comparable units during
heat cycles. Built-in heating elements can be supplied
on the glass. The suffix G is added to the model number.
A small controller keeps the temperature constant between
34-50 deg. C. This option eliminates the objection of
the glass acting as a heat sink. A footswitch is supplied
and allows the start of the test and the reset of the
readout as well as the start, stop and reset button on
the front panel.
Part #
390 Plantar Test (Hargreaves
test)
390G Plantar Test (Hargreaves test) with heated glass option
Two Year Warranty and CE
Certified
Dimensions:
17" X 17" X 5.25"
Base 36" X 15.75" X 3.25" (Heated)
Base 36" X 15.25" X 5" (Non-Heated)
Glass 35.625" X 14" X .25"
Animal Enclosure 27" X 8.625" X 5"
Partial
List of Literature References:
SPINAL
GLUTAMATE UPTAKE IS CRITICAL FOR MAINTAINING NORMAL
SENSORY
TRANSMISSION IN RAT SPINAL CORD
Yuan-Xiang Tao,Rothstein et al.
Pain 115(2005) 60-70
INCREASED
NOCICEPTIVE RESPONSE IN MICE LACKING THE ADENOSINE
A1 RECEPTOR
Wei-Ping Wu, Jing-Xia
Hao, Linda Halldner, Cecilia Lovdahl, Gary E. DeLander,
Zsuzsanna Wiesenfeld-Hallin, Bertil B. Fredholm, Xiao-Jun
Xu
Pain 113 (2005) 395-404,
A
RAT MODEL OF UNILATERAL HIND PAW BURN INJURY: SLOWLY
DEVELOPING RIGHTWARDS SHIFT OF THE MORPHINE DOES-RESPONSE
CURVE
Shuxing
Wang, Grewo Lim, Liling Yang, Oing Zeng, Backil Sung,
J.A. Jeevendra Martyn, Jianren Mao
Pain 116 (2005) 87-89
More Literature referenfces upon request